Oops, I Did It Again: New brain research may help explain why some people don't seem to learn from their mistakes.

[24 April 2007 - Newsweek] Benjamin Franklin was no brain scientist. He was a keen observer of human behavior, and of the natural world, but he was a couple centuries too early to explore the intricate neuronal interplay of physics and biochemistry that makes us the people we are: healthy, wise, quirky, self-destructive. So, when he famously defined insanity as "doing the same thing over and over and expecting different results," this 18th-century polymath was really being more intuitive than rigorously scientific. Yet it looks like he got it right. New neuropsychological research is now suggesting that the inability to learn from one's mistakes may indeed be at the root of a broad range of human problems, ranging from childhood bullying and truancy to aggressive acts like road rage to all manner of substance abuse. And this cognitive aberration, deep-wired into the neurons and genes, may even underlie the vagaries of normal human behavior and personality. (It's important in the wake of the tragic events at Virginia Tech to emphasize that this column is not about such deeply disturbed psychology.) More